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Rx drug information, pharmaceutical research, clinical trials, news, and more drugs by name by condition by category most searched ratings/reviews drug q&a adverse events actives related drugs aricept donepezil in treating young patients with primary brain tumors previously treated with radiation therapy to the brain information source: national cancer institute (nci) information obtained from clinicaltrials. Gov on october 19, 2009 link to the current clinicaltrials. Gov record. Condition(s) targeted: brain and central nervous system tumors; cognitive/functional effects; long-term effects secondary to cancer therapy in children; neurotoxicity; psychosocial effects of cancer and its treatment; radiation toxicity intervention: donepezil hydrochloride (drug); cognitive assessment (procedure); psychosocial assessment and care (procedure); quality-of-life assessment (procedure); ultrasound imaging (procedure) phase: n/a status: recruiting sponsored by: wake forest university official(s) and/or principal investigator(s): sharon m. Castellino, md, faap, study chair, affiliation: wake forest university summary rationale: donepezil may decrease the side effects caused by radiation therapy to the brain. Purpose: this clinical trial is studying how well donepezil works in treating young patients with primary brain tumors previously treated with radiation therapy to the brain. Clinical details official title: a pilot study of donepezil hydrochloride in pediatric brain tumor survivors after cranial irradiation study design: supportive care, open label, active control primary outcome: effect of donepezil hydrochloride on neurocognitive function as measured by the neurocognitive battery at 24 weeks secondary outcome: comparison of baseline dynamic vascular analysis (dvaâ„¢) indices in pediatric patients who score < 70 vs pediatric patients who score > 70 on the peabody picture vocabulary test-3correlation of changes in dvaâ„¢ indices with changes in cognitive functionhealth-related quality of life (qol) as measured by child report of qol and pediatric qol inventory (parent and child components) at baseline and at 12, 24, and 36 weeksfamily impact as measured by life events, pediatric inventory for parents, and impact on family at week 24toxicity as measured by nci ctcae v3. 0barriers to recruitment and retention of pediatric patients detailed description: objectives: primary - determine the impact of donepezil hydrochloride on cognitive function in pediatric patients with primary brain tumors previously treated with cranial radiotherapy. Secondary - assess health-related qual.
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